Several of my friends performed as singles on cruise ships, 2 as headliners (Bobby Raye and Bobby Burnett) and one as a "one man band" with an arranger module.
Gene Lovello from the Bay Area is/was a solo artist with Princess Cruise Lines aboard the "Love Boat". Gene played a Petosa midi accordion with a Solton arranger ... mostly used his own sequences. I used to correspond with him via snail mail (pre computer days). The last I heard from him, he was trying to sell his equipment. I would guess that he is no longer performing as he met a very pretty lady on one of the cruises and she may have influenced his selling his beloved Petosa.
So, the answer to your question is, Yes it is possible.
Ciao,
Jerry