That Karma engine would be so cool for doing ad soundtracks, or radio donuts.
When we first started doing them, we used a constantly cantankerous Polymoog and an old 16-step analog sequencer...and no MIDI.
As the old saying goes, "You've come a long way, baby!"
Ian
When I was doing Ads, right after college, we used real live musicians playing antiquated things known at the time as trumpets, drums, pianos, B3s. Back in Oklahoma we used tom-toms and snake rattles. I don't think sequencer was even a word yet!

Don