If your arranger has Direct Outs, probably no problem. Just feed it the guitar part, or whatever is doing a full chord.

But I imagine an entire mix would give mixed result. There's a lot of passing notes by the time you have it listen to every note played. Plus none pitched stuff (drums and percussion) that might effect it (maybe it might try to follow the pitch of the toms, on an exposed fill!).

Generally, if it did a good job with a full mix, it would say it on the product... That it doesn't probably indicates the makers tried it and it failed.