I spoke with Bose technical gurus today and they said there is no difference in running mono or RCA stereo. They did encourage to experiment for myself and I may hear a difference.
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Live: Korg PA4X/EV Everse 8s/Senn 935/K&M stand

Studio: Korg PA4X/Yamaha DGX670/Nord 6D73/Boss BR900CD/Tascam DP24SD/MTM Iloud/Sony C80/AGK 214/ATEM Mini Pro switcher/K&M stand