I usually play the chord that is comfortable for my vocals, which often varies quite a bit from the chord the song was written in. The vast majority of the songs I sing, however, are usually performed in the chord of "A" or "C".
Gary

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PSR-S950, TC Helicon Harmony-M, Digitech VR, Samson Q7, Sennheiser E855, Custom Console, and lots of other silly stuff!
K+E=W (Knowledge Plus Experience = Wisdom.)