I have the 5080 and have not heard the 5050, but, from what I read, there should be no difference in sound quality. The main difference is in expandability. However, the difference is not what it used to be now that JV cards have been "folded into" SRX cards. I think the 5050 is a good bet. The 5080 is in its 3rd year and may be due for a replacement, e.g., with 8 SRX slots and no JV slots.