hi marcK,
you mean 1. unpowered mixer to an amplifier and then to the speakers? or 2.powered mixer to unpowered speakers, or 3.unpowered mixer to powered speakers?.....for 1, going from the amp to the speakers you do not need either balanced or unbalanced cable, just use figure 8 cable (at least 1.5swg) from the mixer to the amp either a balanced or unbalanced cable should be used, if the length required from the mixer to the amp is more than about 15 feet it is recommended to use a balanced cable...for number 2, figure 8 cable(min 1.5 swg) for number 3, if the cable run is less than about 15 feet it does not make much difference, more than that, use the balanced cables...btw you sometimes see speaker cables that run from amps to speakers that use the xlr connector, these are not balanced, the xlr connector is used for connection strength. they are also wired differently with hot(+) being pin 3, cold(-) pin 1, and pin 2 is not used (pin 2 is the hot pin on normal microphone/instrument use).
hope that helps some...
cheers
dennis