Main problem I have with it is that it doesn't run the industry standard DAW's... ProTools, Cubase4, Sonor, Logic, Nuendo etc..
While Linux offers much in the way of audio prioritizing in the OS, the apps that run on it are in their infancy, and don't offer as well tested, powerful and elegant audio solutions. Things may improve in time, but for now, I'm more concerned with the APP than the OS it runs on...
Using Linux dramatically reduces your choices when it comes to audio tools of choice, plug-ins that run on PCI cards (no UAD Linux, no Duende, no TC stuff), and a VERY limited selection of VSTi's that run reliably on it...
But, what the hey! It LOOKS neat...